Inhibition of Intimal Thickening After Balloon Angioplasty in Porcine Coronary Arteries
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چکیده
Adelman, James Chesebro, John Fallon, Valentin Fuster, Andrew Marks and Juan José Richard Gallo, Adrian Padurean, Thottala Jayaraman, Steven Marx, Merce Roque, Steven by Targeting Regulators of the Cell Cycle Inhibition of Intimal Thickening After Balloon Angioplasty in Porcine Coronary Arteries Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 1999 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.99.16.2164 1999;99:2164-2170 Circulation. http://circ.ahajournals.org/content/99/16/2164 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Angiopeptin inhibits intimal hyperplasia after angioplasty in porcine coronary arteries.
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BACKGROUND Although percutaneous transluminal coronary angioplasty (PTCA) is a highly effective procedure to reduce the severity of stenotic coronary atherosclerotic disease, its long-term success is significantly limited by the high rate of restenosis. Several cellular and molecular mechanisms have been implicated in the development of restenosis post-PTCA, including vascular smooth muscle cel...
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BACKGROUND Previous studies in animal models of angioplasty have suggested a role in neointimal hyperplasia for endothelins (ETs), potent vasoconstricting peptides that also exert growth-promoting effects. The present studies were undertaken to test the hypothesis that endothelin receptor blockade can reduce neointimal thickening in injured porcine coronary arteries. METHODS AND RESULTS An ET...
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Inhibition of proliferative neointima formed by vascular smooth muscle cells is a potential target in preventing angioplasty-induced restenosis. We have created a potent antiproliferative by fusing the active regions of the p27 and p16 cell cycle inhibitors. Intravascular delivery of a replication-deficient adenoviral vector (AV) encoding this p27-p16 fusion protein, named W9, inhibited balloon...
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Percutaneous transluminal coronary angioplasty is a frequently used interventional technique to reopen arteries that have narrowed because of atherosclerosis. Restenosis, or renarrowing of the artery shortly after angioplasty, is a major limitation to the success of the procedure and is due mainly to smooth muscle cell accumulation in the artery wall at the site of balloon injury. In the presen...
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